Sitamaquine hydrochloride
Product Specifications
CAS Number
5330-29-0
Target
Parasite, Histamine Receptor, Mitochondrial Metabolism
Related Pathways
Immunology/Inflammation, Neuroscience, Microbiology/Virology, GPCR/G Protein, Metabolism
Bioactivity
Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.
Smiles
COC1=CC2=C(C)C=CN=C2C(NCCCCCCN(CC)CC)=C1.Cl.Cl
Molecular Formula
C21H35Cl2N3O
Molecular Weight
416.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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