AZ 14145845
Product Specifications
CAS Number
2830555-70-7
Bioactivity
AZ 14145845, a potent and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively), demonstrates significant efficacy in reducing tumor growth in a dose-dependent manner within the Mer and Axl kinase Ba/F3 tumor xenograft model in vivo. When combined with anti-PD1 antibodies and ionizing radiation, this compound enhances survival rates in mice bearing MC38-derived tumors. Additionally, AZ 14145845 is orally bioavailable.
Smiles
N=1N=C(OC1C=2N=CC(=CC2C)C=3C(=NN(C3C)C)C)N(C)CC=4C=CC5=NC=C(C=6C=CC(=CC6)CN(C)C)N5C4
Molecular Formula
C32H35N9O
Molecular Weight
561.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-20746R-BF555-TR 20 µL
GPR49/LGR5 Polyclonal Antibody, AbBy Fluor™ 555 Conjugated
Sign In for Pricing
View Details 
LV628253 1.0 µg DNA
Olr1055 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
MBS6145813-01 0.1 mL
AES (Amino-terminal Enhancer of Split, Amino Enhancer of Split, Gp130-Associated Protein GAM, Protein ESP1, Protein GRG, GRG) (FITC)
Sign In for Pricing
View Details