AZ 14145845
Product Specifications
CAS Number
2830555-70-7
Bioactivity
AZ 14145845, a potent and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively), demonstrates significant efficacy in reducing tumor growth in a dose-dependent manner within the Mer and Axl kinase Ba/F3 tumor xenograft model in vivo. When combined with anti-PD1 antibodies and ionizing radiation, this compound enhances survival rates in mice bearing MC38-derived tumors. Additionally, AZ 14145845 is orally bioavailable.
Smiles
N=1N=C(OC1C=2N=CC(=CC2C)C=3C(=NN(C3C)C)C)N(C)CC=4C=CC5=NC=C(C=6C=CC(=CC6)CN(C)C)N5C4
Molecular Formula
C32H35N9O
Molecular Weight
561.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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