D34-919
Product Specifications
CAS Number
1011641-78-3
Target
Dehydrogenase, PKM
Related Pathways
Metabolism
Bioactivity
D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.
Smiles
N#CC=1C(=NC(=NC1N2CCC(C(=O)N)CC2)SC)C=3C=CC(=CC3)C(C)(C)C
Molecular Formula
C22H27N5OS
Molecular Weight
409.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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