ZX703
Product Specifications
Target
PROTACs, Ferroptosis, Reactive Oxygen Species, Glutathione Peroxidase
Related Pathways
Apoptosis, Metabolism, PROTAC, NF-κB, Immunology/Inflammation
Bioactivity
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 μM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.
Smiles
[C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)(NC(CCCCCCCCCCCCCCCCCCCCCC)=O)CO
Molecular Formula
C41H83NO4
Molecular Weight
654.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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