AZD8421
Product Specifications
CAS Number
3047321-53-6
Bioactivity
AZD8421 is a potent and highly selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 9nM, demonstrating greater selectivity over CDK1, CDK4, and CDK6. This compound also exhibits antiproliferative properties by effectively inhibiting Rb phosphorylation. In models of breast and ovarian cancer, AZD8421 has shown significant activity both as a monotherapy and in combination with CDK4/6 inhibitors.
Smiles
N(C1=C2C(N(CC)C=N2)=NC(N[C@H]([C@@H](C)O)CC)=N1)[C@@H]3CN(S(NCC)(=O)=O)CC3
Molecular Formula
C18H32N8O3S
Molecular Weight
440.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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