ART899
Product Specifications
CAS Number
2607139-85-3
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
ART899, a derivative of ART558, is a potent and specific conformational inhibitor of DNA polymerase ? (Pol?) . It specifically inhibits the MMEJ activity of Pol? with an IC50 of 180 nM. Additionally, ART899 selectively enhances the radiosensitivity of tumor cells and possesses a strong independent antitumor effect on cancer cells.
Smiles
C(N(C([2H])([2H])[2H])C1=CC(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)[C@@H](O)[C@H]2O)C3=CC(C(F)(F)F)=CC(C)=N3
Molecular Formula
C19H16ClF4N3O4
Molecular Weight
464.81
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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