CGamF

CGamF is a fluorescent probe designed for bile acid transport, consisting of a bile acid (Product No. 20250) linked to fluorescein via a glycine connecting group. In aqueous solution at pH 7.4, the excitation/emission wavelengths of this probe are 492/515 nm, respectively. The fluorescence intensity of CGamF increases with rising pH when excited at 495 nm, while the intensity is unaffected by pH changes when excited at 440 nm. Sodium-dependent uptake of CGamF by hepatocytes increases with the concentration of the compound, with reduced absorption at lower sodium levels. CGamF has been utilized in vitro to study drug interactions and toxicity mediated by hepatic transporters.

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