HPG1860
Product Specifications
CAS Number
2226133-29-3
Target
FXR
Related Pathways
Metabolism
Bioactivity
HPG1860, an agonist of the farnesoid X receptor (FXR), induces luminescence in reporter gene assays utilizing HEK293T cells expressing human FXR, with an EC50 value of 18 nM. In vivo studies demonstrate that HPG1860 (administered at 1, 3, or 10 mg/kg daily) reduces serum alanine aminotransferase (ALT) and total cholesterol levels in a mouse model of non-alcoholic steatohepatitis (NASH), which was induced by a high-fat diet and carbon tetrachloride (CCl4) . Additionally, this compound decreases hepatic inflammation, fat levels, and fibrosis.
Smiles
C(C=1C(=NOC1C2CC2)C3=C(Cl)C=CC=C3Cl)N4C[C@@H](C)N(CC4)C5=NC=6C(S5)=CC(C(O)=O)=CC6OC
Molecular Formula
C27H26Cl2N4O4S
Molecular Weight
573.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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