SIAIS562055
Product Specifications
Target
Ras, PROTACs
Related Pathways
GPCR/G Protein, MAPK, PROTAC
Bioactivity
SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.
Molecular Formula
C49H62F3N7O5S
Molecular Weight
918.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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