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BRD-K20733377

Product Specifications

CAS Number

452350-43-5

Target

Bcl-2 Family

Related Pathways

Apoptosis

Bioactivity

BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.

Smiles

O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CC=N2)C=3C=CC(=CC3)C=4C=CC=CC4

Molecular Formula

C23H18N4O3S

Molecular Weight

430.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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