BRD-K20733377
Product Specifications
CAS Number
452350-43-5
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 ?M. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CC=N2)C=3C=CC(=CC3)C=4C=CC=CC4
Molecular Formula
C23H18N4O3S
Molecular Weight
430.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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