YJ9069
Product Specifications
Target
DNA/RNA Synthesis, PROTACs, CDK
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, PROTAC
Bioactivity
YJ9069 is a selective CDK12/CDK13P ROTAC degrader with an IC50 of 22.22 nM in VCaP cells. Rapid degradation of CDK12/13 by this compound triggers transcription elongation defects dependent on gene length, leading to DNA damage and cell cycle arrest. YJ9069 effectively inhibits the proliferation of prostate cancer cell subpopulations and significantly suppresses prostate tumor growth in vivo.
Smiles
FC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2
Molecular Formula
C46H46N10O7
Molecular Weight
850.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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