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WRN inhibitor 11

Product Specifications

CAS Number

3058317-61-3

Target

DNA/RNA Synthesis

Related Pathways

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.

Smiles

O=C(C1=NC=NC(=C1O)C)N2CC3N(C=4C(=O)N5N=C(N=C5N(C4CC)CC(=O)NC6=CC(Cl)=C(C=C6C)C(F)(F)F)C7=CCOCC7)C(C2)CC3

Molecular Formula

C34H35ClF3N9O5

Molecular Weight

742.15

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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