Tubulin polymerization-IN-70
Product Specifications
Target
Reactive Oxygen Species|||Apoptosis|||Microtubule Associated
Related Pathways
Cytoskeletal Signaling|||Metabolism|||Apoptosis|||Immunology/Inflammation|||NF-?B
Bioactivity
Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS) . Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.
Smiles
[C@@H](NC(=O)C=1N(CC)N=CC1)(C(NC2=C(F)C=C([C@@H](C(C(=O)N3C[C@@H](C)N(C)CC3)NC(C(F)C4CC4)=O)C)C=C2)=O)[C@]5(CC[C@H](C)CC5)[H]
Molecular Formula
C25H23N3O2
Molecular Weight
397.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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