PROTAC SMARCA2 degrader-21
Product Specifications
CAS Number
2891464-61-0
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.
Smiles
O=C(NCC=1C=CC(=CC1)C=2SC=NC2C)C3N(C(=O)C(NC(=O)C4CC5(C4)CC(N6CCC(C7=NC(=NC=C7)N8CCN9C%10=CC(=NN=C%10NCC9C8)C=%11C=CC=CC%11O)CC6)C5)C(C)(C)C)CC(O)C3
Molecular Formula
C54H66N12O5S
Molecular Weight
995.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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