EGFR-IN-131
Product Specifications
Target
Apoptosis|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Apoptosis
Bioactivity
EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0/G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.
Smiles
C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)[C@H](CC)C)=O)CCCCN)=O)CC(C)C)=O)CO)=O)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)C)=O)[C@H](CC)C)=O)CO)=O)=O)CCSC)=O)CO)=O)[C@@H](C)O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCCN)=O)CO)=O)C=1C=2C(NC1)=CC=CC2
Molecular Formula
C26H23FN4O2S
Molecular Weight
474.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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