I194496
Product Specifications
CAS Number
445238-07-3
Target
Annexin A, Akt, VEGFR, FAK, ERK, PI3K, Ras, Raf, STAT, Others
Related Pathways
Cytoskeletal Signaling, GPCR/G Protein, MAPK, Others, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling, Angiogenesis
Bioactivity
I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)NC=2C=CC=CC2OC)C=3C=NN4C3N=C(C=C4C(F)F)C=5C=CC(OC)=CC5
Molecular Formula
C28H23F2N5O5S
Molecular Weight
579.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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