PROTAC SMARCA2 degrader-22
Product Specifications
CAS Number
2760246-90-8
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader designed to degrade SMARCA2, achieving a degradation efficacy of 94% at 100 nM. This compound also inhibits the proliferation of A549 cells with an EC50 of less than 250 nM.
Smiles
C([C@@H](NC(CN1CCN(CC1)C2=CC=C(C=N2)C=3C=C(N=NC3)C4=C(O)C=CC=C4)=O)[C@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5
Molecular Formula
C44H51N9O5S
Molecular Weight
818
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/264724928220102659/T201090
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