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Claturafenib

Product Specifications

CAS Number

2754408-94-9

Target

PERK, Raf

Related Pathways

Apoptosis, MAPK

Purity

≥99.99%

Bioactivity

Claturafenib (PF-07799933) is a brain-permeable, selective, all-mutant BRAF inhibitor with broad inhibitory effects on pERK levels in HT29 cells.Claturafenib has shown antitumor activity in preclinical studies in both BRAF V600- and non-V600-mutant cancers and can be used in combination with MEK inhibitors.

Smiles

O=C1C2=C(N=CN1C)C=CC(NC=3C(F)=CC=C(NS(=O)(=O)N4CC(F)C4)C3Cl)=C2Cl

Molecular Formula

C18H15Cl2F2N5O3S

Molecular Weight

490.31

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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