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Metallo-?-lactamase-IN-16

Product Specifications

CAS Number

2058069-25-1

Target

Antibacterial|||Beta-lactamase

Related Pathways

Microbiology/Virology

Bioactivity

Metallo-?-lactamase-IN-16 (compound 18), a sulfone-containing metallo-?-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-?-lactamases, including NDM-1 (New Delhi metallo-?-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-?-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.

Smiles

O=S(=O)(N)C1=C(C2=NN=NN2)C(=CC=C1S(=O)(=O)CCN)C=3C=CC=C4SC(=NC43)N

Molecular Formula

C16H16N8O4S3

Molecular Weight

480.54

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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