NLRP3-IN-55
Product Specifications
Target
Pyroptosis, NOD-like Receptor (NLR)
Related Pathways
Apoptosis, Immunology/Inflammation
Bioactivity
NLRP3-IN-55 (Compound 19) is an effective inhibitor of NLRP3, exhibiting an inhibitory concentration (IC50) of 0.34 μM. It targets the NLRP3 protein directly with a dissociation constant (KD) of 0.45 μM, effectively blocking the assembly and activation of the NLRP3 inflammasome. This action results in anti-inflammatory effects and inhibits cell pyroptosis.
Smiles
O=C(NCCC=1C=CC=CC1)C2=NOC(=C2)C=3C=CC(F)=CC3
Molecular Formula
C32H30ClFN2O4
Molecular Weight
561.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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