KRAS G12D inhibitor 25
Product Specifications
CAS Number
2768099-61-0
Target
Ras, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, JAK/STAT signaling, Angiogenesis, GPCR/G Protein
Bioactivity
KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.
Smiles
O(C[C@H]1CN(C(=O)C2CCN(CC3=CC=C(C=C3)N4C(=NNC4=O)C5=CC(C(C)C)=C(O)C=C5O)CC2)CCC1)C6=NC(=C7C(CN(CC7)C=8C9=C(C=CC8)C=CC=C9Cl)=N6)N%10C[C@H](CC#N)N(C(C=C)=O)CC%10
Molecular Formula
C56H62ClN11O6
Molecular Weight
1020.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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