TOPOI/PARP-1-IN-2
Product Specifications
Target
PARP, Apoptosis, Topoisomerase
Related Pathways
Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.
Smiles
[Na].O=C(NC=1C(=CC(Cl)=CC1C(C)C)C(C)C)NS(=O)(=O)C=2OC=C(C2)C(O)(C)C
Molecular Formula
C16H11ClN4O2S
Molecular Weight
358.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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