PROTAC SMARCA2 degrader-24
Product Specifications
CAS Number
2755761-70-5
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC SMARCA2 degrader-24 (Compound 34) is a SMARCA2 PROTAC degrader with a DC50 of less than 0.1 μM in HeLa cells. It also degrades SMARCA4 in HeLa cells, exhibiting a DC50 greater than 10 μM.
Smiles
C(CN(CCC=1C=C(C(C(=O)N2[C@H](C(N[C@@H](C)C3=CC=C(C=C3)C=4SC=NC4C)=O)C[C@@H](O)C2)C(C)C)ON1)C)N5C[C@]6(N(C=7C(NC6)=NN=C(C7)C8=C(O)C=CC=C8)CC5)[H]
Molecular Formula
C45H56N10O5S
Molecular Weight
849.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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