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SZU-B6

Product Specifications

CAS Number

3059333-98-8

Target

Sirtuin|||PROTACs|||Apoptosis

Related Pathways

PROTAC|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic

Bioactivity

SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 ?M and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.

Smiles

O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CN5CCN(C6=CC=C(C(N)=C6)N(=O)=O)CC5)CC4

Molecular Formula

C29H32FN7O6

Molecular Weight

593.61

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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