SZU-B6
Product Specifications
CAS Number
3059333-98-8
Target
Sirtuin|||PROTACs|||Apoptosis
Related Pathways
PROTAC|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 ?M and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.
Smiles
O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CN5CCN(C6=CC=C(C(N)=C6)N(=O)=O)CC5)CC4
Molecular Formula
C29H32FN7O6
Molecular Weight
593.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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