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PI-3065

PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.

Product Specifications

CAS Number

955977-50-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/PI-3065.html

Purity

99.39

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

FC(C=CC1=C2C=CN1)=C2C3=NC4=C(SC(CN5CCN(CC6CC6)CC5)=C4)C(N7CCOCC7)=N3

Molecular Formula

C27H31FN6OS

Molecular Weight

506.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Ali K, et al. Inactivation of PI (3) K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;509 (7505) :407-11.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kα; PI3Kβ; PI3Kδ

Available Sizes

Frequently Asked Questions

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