BCR-ABL-IN-10
Product Specifications
Target
Bcr-Abl
Related Pathways
Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
BCR-ABL-IN-10 (compound B4) is a covalent BCR-ABL inhibitor featuring an arylvinylsulfonate (AVS) moiety, demonstrating an IC50 of 43.1 nM against ABL kinase. It forms a covalent and stable adduct with ABL kinase, enabling the sustained inhibition of intrinsic BCR-ABL activity. This compound is utilized in the study of chronic myeloid leukemia (CML) .
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)C(F)(F)F)C2=CCN(C3=NC=CC=C3C)CC2
Molecular Formula
C24H22N4O5S
Molecular Weight
478.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
