YSY01A

Product Specifications

CAS Number

1194235-46-5

Target

STAT|||JAK|||Proteasome|||Interleukin

Related Pathways

Stem Cells|||Proteases/Proteasome|||Angiogenesis|||Immunology/Inflammation|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Ubiquitination|||Chromatin/Epigenetic

Bioactivity

YSY01A is a proteasome inhibitor that suppresses cancer cell survival by inducing apoptosis (Apoptosis) . It demonstrates IC50 values against various cell lines such as HEK293T, A549, MCF-7, MGC-803, and PC-3M with values of 51.01, 9.21, 5.21, 8.9, and 35.4 nM respectively. Additionally, YSY01A serves as a degrader of gp130 and JAK2, eliminating constitutive STAT3 signaling in human A549 lung cancer cells by downregulating gp130 and JAK2. YSY01A holds potential for research in cancer therapeutics.

Smiles

C([C@H](NC([C@@H](NC(=O)C=1C=NC=CN1)CC(C)C)=O)C(N[C@@H](CC(C)C)B(O)O)=O)C2=CC3=C(C=C2)C=CC=C3

Molecular Formula

C29H38BN5O5

Molecular Weight

547.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C