YSY01A
Product Specifications
CAS Number
1194235-46-5
Target
STAT|||JAK|||Proteasome|||Interleukin
Related Pathways
Stem Cells|||Proteases/Proteasome|||Angiogenesis|||Immunology/Inflammation|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Ubiquitination|||Chromatin/Epigenetic
Bioactivity
YSY01A is a proteasome inhibitor that suppresses cancer cell survival by inducing apoptosis (Apoptosis) . It demonstrates IC50 values against various cell lines such as HEK293T, A549, MCF-7, MGC-803, and PC-3M with values of 51.01, 9.21, 5.21, 8.9, and 35.4 nM respectively. Additionally, YSY01A serves as a degrader of gp130 and JAK2, eliminating constitutive STAT3 signaling in human A549 lung cancer cells by downregulating gp130 and JAK2. YSY01A holds potential for research in cancer therapeutics.
Smiles
C([C@H](NC([C@@H](NC(=O)C=1C=NC=CN1)CC(C)C)=O)C(N[C@@H](CC(C)C)B(O)O)=O)C2=CC3=C(C=C2)C=CC=C3
Molecular Formula
C29H38BN5O5
Molecular Weight
547.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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