INOs-IN-5
Product Specifications
Target
Apoptosis, NO Synthase
Related Pathways
Apoptosis, Immunology/Inflammation
Bioactivity
INOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056) . It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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