PROTAC SMARCA2/4-degrader-16

PROTAC SMARCA2/4-degrader-16 (compound I-337) serves as a PROTAC degrader targeting both SMARCA2 and SMARCA4 proteins, achieving DC50s values under 100 nM in A549 cells with a Dmax% exceeding 90 after 24 hours of treatment.

NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@H]5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9