PROTAC SMARCA2 degrader-9
Product Specifications
CAS Number
2568276-39-9
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2. It degrades SMARCA2 protein in A549 cells with a DC50 value of less than 100 nM and achieves a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.
Smiles
O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)CCCN4CCN(C5=CN=C(N=C5)N6C7CN(C=8C=C(N=NC8N)C9=CC=CC=C9O)CC6CC7)CC4)C)CC1
Molecular Formula
C40H46N12O4
Molecular Weight
758.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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