What is the catalog number for JNK-1-IN-4?

The catalog number for JNK-1-IN-4 is T200667.

What sizes are available for JNK-1-IN-4?

JNK-1-IN-4 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does JNK-1-IN-4 come in?

JNK-1-IN-4 is available in 3 different pack sizes.

Is JNK-1-IN-4 in stock?

JNK-1-IN-4 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures JNK-1-IN-4?

JNK-1-IN-4 is manufactured by Molfinity.

What is the estimated delivery time for JNK-1-IN-4?

Estimated delivery time for JNK-1-IN-4 is approximately 10 business day(s), depending on your location.

JNK-1-IN-4

Product Specifications

CAS Number

3047795-60-5

Target

JNK

Related Pathways

MAPK

Bioactivity

JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA) . JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.