JNK-1-IN-4
Product Specifications
CAS Number
3047795-60-5
Target
JNK
Related Pathways
MAPK
Bioactivity
JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA) . JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.
Smiles
O=C(N)C1=CC(OCCN(C)C)=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(OC)C=C3
Molecular Formula
C22H25BrN6O3
Molecular Weight
501.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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