SLC7A11-IN-2
Product Specifications
CAS Number
14668-59-8
Target
Others, Reactive Oxygen Species
Related Pathways
Immunology/Inflammation, Metabolism, Others, NF-κB
Bioactivity
SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.
Smiles
O=C(NNC=1C=CC=CC1)C(C(=O)NNC=2C=CC=CC2)CC(O)CC
Molecular Formula
C19H24N4O3
Molecular Weight
356.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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