SLC7A11-IN-2
Product Specifications
CAS Number
14668-59-8
Target
Others, Reactive Oxygen Species
Related Pathways
Immunology/Inflammation, Metabolism, Others, NF-κB
Bioactivity
SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.
Smiles
O=C(NNC=1C=CC=CC1)C(C(=O)NNC=2C=CC=CC2)CC(O)CC
Molecular Formula
C19H24N4O3
Molecular Weight
356.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
45745111 3x 1.0 µg
STK33 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
Sign In for Pricing
View Details 
P4073-30L-Biotin 100 µL
Phosphoinositide 3 Kinase, p85 beta (PI-3 Kinase p85 beta, PI3 Kinase p85 beta Subunit, PI3 Kinase p85 Subunit beta, PI3K, p85 beta, P85B, Phosphatidylinositol 3 Kinase Regulatory beta Subunit, Phosphatidylinositol 3 Kinase Regulatory Subunit beta, Phosphatidylinositol 3 Kinase Regulatory Subunit Polypeptide 2, Phosphoinositide 3 Kinase Regulatory Subunit 2 (beta), Phosphoinositide 3 Kinase Regulatory Subunit Polypeptide 2 (p85 beta), PIK3R2, PtdIns-3-kinase p85 beta) (Biotin)
Sign In for Pricing
View Details