Anti-osteoporosis agent-11
Product Specifications
CAS Number
2869099-50-1
Target
NF-κB, p38 MAPK, RANKL/RANK
Related Pathways
NF-κB, MAPK
Bioactivity
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.
Smiles
O=C1C([Se]C=2C=CC=CC2)=C([Se]C=3C=CC=CC3)C(=O)N1CC=4C=CC=CC4
Molecular Formula
C23H17NO2Se2
Molecular Weight
497.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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