Ingenol 3-monobenzoate
Product Specifications
CAS Number
83036-64-0
Target
PKC
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic
Bioactivity
Ingenol 3-monobenzoate (Ingenol 3-benzoate) acts as an aversive inducing agent. It binds to and activates protein kinase C (PKC) with a Ki of 0.14 nM. This activation inhibits the gene expression of phosphoenolpyruvate carboxykinase, thereby suppressing gluconeogenesis and increasing blood cortisol levels, which results in food aversion.
Smiles
O[C@@]12[C@@]3(C(=O)[C@]([C@]4([C@@](C[C@H]3C)(C4(C)C)[H])[H])(C=C(CO)[C@H]1O)[H])C=C(C)[C@@H]2OC(=O)C5=CC=CC=C5
Molecular Formula
C27H32O6
Molecular Weight
452.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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