HDGFRP2/PSIP1-IN-1
Product Specifications
CAS Number
166196-54-9
Target
Others|||DNA/RNA Synthesis
Related Pathways
Others|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Bioactivity
Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG) . It demonstrates binding affinity with a Kd value of 7 ?M for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 ?M when binding to the PSIP1 PWWP domain, and a Kd value of 14 ?M against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.
Smiles
BrC1=CNN=C1C=2C=CN=CC2
Molecular Formula
C8H6BrN3
Molecular Weight
224.06
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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