PF-07957472
Product Specifications
CAS Number
3041047-51-9
Target
SARS-CoV, Virus Protease
Related Pathways
Microbiology/Virology
Bioactivity
PF-07957472 (Compound 4) is an orally effective inhibitor of the SARS-CoV-2 papain-like protease (PLpro) . In NHBE cells infected with SARS-CoV-2, it demonstrated cytopathic effects with an EC50 of 13.9 nM. Additionally, PF-07957472 exhibited antiviral activity in a mouse-adapted COVID-19 infection model.
Smiles
O=C(NC1(C=2C=C(N=C3C=CC=CC32)C=4C=NN(C4)C)CC1)C5=CC(=CC=C5C)N6CCN(C)CC6
Molecular Formula
C29H32N6O
Molecular Weight
480.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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