NA-Ir
Product Specifications
CAS Number
3031762-97-4
Target
Mitochondrial Metabolism|||STING|||Ferroptosis|||Autophagy
Related Pathways
Metabolism|||Autophagy|||Immunology/Inflammation|||Apoptosis
Bioactivity
NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy () . It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.
Smiles
F[P-](F)(F)(F)(F)F.[N-]=[N+]=NC1=CC=C2C(N(CCC(OCC3=CC(C4=CC(C)=CC=[N]4[Ir+3]567([C-]8=C(C9=[N]7C=CC=C9)C=CC=C8)[C-]%10=C(C%11=[N]6C=CC=C%11)C=CC=C%10)=[N]5C=C3)=O)C(C%12=CC=CC1=C%122)=O)=O
Molecular Formula
C49H36F6IrN8O4P
Molecular Weight
1138.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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