10-Methoxy-canthin-6-one
Product Specifications
CAS Number
86293-40-5
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC) . Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.
Smiles
O=C1C=CC2=NC=CC=3C4=CC(OC)=CC=C4N1C23
Molecular Formula
C15H10N2O2
Molecular Weight
250.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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