PROTAC SMARCA2/4-degrader-33
Product Specifications
CAS Number
2568276-36-6
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2/4-degrader-33 (compound I-277) functions as a degrader targeting the proteins SMARCA2 and SMARCA4, exhibiting DC50s values of less than 100 nM for the degradation of SMARCA2/4 in A549 cells. After a treatment period of 24 hours, the maximum degradation rates (Dmax%) consistently exceed 90%.
Smiles
NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5CCN(CC5)[C@H]6CC[C@H](CC6)C=7C=C8C(=CC7)N(C(=O)N8C)C9C(=O)NC(=O)CC9)C=C(N=N1)C%10=C(O)C=CC=C%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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