MS41
Product Specifications
CAS Number
2768610-97-3
Target
Epigenetic Reader Domain|||Apoptosis|||PROTACs
Related Pathways
PROTAC|||Chromatin/Epigenetic|||Apoptosis
Bioactivity
MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1) . This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis) . Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.
Smiles
N(C(=O)C=1C=C(ON1)C2=CC(O)=C(C(N(C)C)=O)C=C2)[C@H]3C=4C(CC3)=CC=C(C(NCCCCCCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)C4
Molecular Formula
C56H70N8O9S
Molecular Weight
1031.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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