PROTAC GSPT1 degrader-1
Product Specifications
CAS Number
3034310-17-0
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC-based degrader that effectively targets and degrades G1 to S phase transition protein 1 (GSPT1), achieving degradation rates of 95% at 1 μM and 86% at 0.1 μM. Additionally, this compound inhibits the viability of HL-60 cells with an IC50 of 9.2 nM.
Smiles
O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CC(C4)CCN5C(=O)N(C=6C=CC=C(C6)C=7C=NC=8NC=C(C8C7Cl)CC)CCC5)CC1
Molecular Formula
C37H36ClN7O5
Molecular Weight
694.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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