NOD1/2-IN-1
Product Specifications
Target
NOD-like Receptor (NLR) |||RIP kinase
Related Pathways
Immunology/Inflammation|||NF-?B|||Apoptosis
Bioactivity
NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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