PPAR? agonist 11

Compound 11, a selective PPAR? agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPAR? receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNF? and IL-6 in LPS-stimulated RAW264.7 cells via the NF-?B pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.