Antiproliferative agent-57
Product Specifications
Target
PI3K, HIF/HIF Prolyl-Hydroxylase, mTOR, VEGFR, Akt, p38 MAPK
Related Pathways
Chromatin/Epigenetic, PI3K/Akt/mTOR signaling, Metabolism, Cytoskeletal Signaling, MAPK, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor that suppresses VEGF secretion in SiHa cells under hypoxic conditions without inducing cytotoxicity (IC50=0.68 μM) . It modulates the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells, thereby inhibiting the expression of HIF-1α and VEGF within tumor tissues.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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